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Semax Information

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2D Structure of Semax
2D Structure

What is Semax?

Semax is a nootropic drug that was developed in Russia. It's derived from a fragment of the adrenocorticotropic hormone (ACTH), specifically the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It is primarily used in Russia and some Eastern European countries for its cognitive and neuroprotective effects. Semax is often prescribed for a variety of conditions, including:

  • Cognitive disorders
  • Memory improvement
  • Stroke recovery
  • Optic nerve diseases
  • ADHD and other attention-related issues

 

How Does Semax Work?

Semax is a synthetic peptide that exerts its effects through various mechanisms:

  1. Neuroprotection: Semax has been shown to have neuroprotective properties, which means it can help protect neurons from damage. This is particularly important in conditions like stroke or traumatic brain injury.
  2. Cognitive Enhancement: It enhances cognitive function by modulating neurotransmitter systems. It particularly influences the cholinergic system, which is crucial for memory and learning.
  3. Neurotrophic Effects: Semax increases the levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which are essential for the growth, maintenance, and survival of neurons.
  4. Modulation of Gene Expression: It can affect the expression of certain genes involved in stress response, inflammation, and neuroplasticity.
  5. Anti-Anxiety and Antidepressant Effects: Some studies suggest that Semax may have anxiolytic and antidepressant properties, potentially due to its action on neurotransmitter systems and neurotrophic factors.

 

Safety and Side Effects

Semax is generally considered safe when used as prescribed, with few reported side effects. However, some individuals may experience:

  • Mild irritation of the nasal mucosa
  • Headache
  • Increased irritability or restlessness

As with any drug, it's important to consult with a healthcare provider before starting Semax to ensure it's appropriate for your specific condition and to understand the correct dosage and potential interactions with other medications.

Synonyms of Semax

  • Semax
  • 80714-61-0
  • ACTH (4-7), Pro-Gly-Pro-
  • MEHFPGP
  • Met-Glu-His-Phe-Pro-Gly-Pro
  • I5FAL2585H
  • ACTH (4-7), prolyl-glycyl-proline-
  • Pro-gly-pro-acth (4-7)
  • UNII-I5FAL2585H
  • L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline
  • SEMAX ACETATE
  • (2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid
  • L-Proline, 1-(N-(1-(N-(N-(N-L-methionyl-L-alpha-glutamyl)-L-histidyl)-L-phenylalanyl)-L-prolyl)glycyl)-
  • Semax?
  • H-Met-Glu-His-Phe-Pro-Gly-Pro-OH
  • SCHEMBL7200319
  • GLXC-25922
  • HY-P1146
  • AKOS040744795
  • Met-Glu-His-Phe-Pro-Gly-Pro [WHO-DD]
  • CS-0028296
  • A864658
  • methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline
  • L-Methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline
  • L-PROLINE, L-METHIONYL-L-.ALPHA.-GLUTAMYL-L-HISTIDYL-L-PHENYLALANYL-L-PROLYLGLYCYL-
  • L-PROLINE, L-METHIONYL-L-alpha-GLUTAMYL-L-HISTIDYL-L-PHENYLALANYL-L-PROLYLGLYCYL-
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