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Sibutramine HCL is a medication that was previously used for weight loss. It works by affecting chemicals in the brain that control appetite and satiety. Specifically, it inhibits the reuptake of certain neurotransmitters, such as serotonin, norepinephrine, and dopamine, which leads to increased levels of these chemicals in the brain. This, in turn, helps to reduce appetite and promote a feeling of fullness, thereby aiding in weight loss. However, it is important to note that Sibutramine HCL has been withdrawn from the market in many countries due to safety concerns, particularly its association with an increased risk of cardiovascular events.