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Cagrilintide Information
Click here to view all Cagrilintide productsThe information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.
Cagrilintide is an investigational peptide that is generating significant interest in the field of metabolic medicine, primarily as a potential treatment for obesity and related metabolic disorders. It is a long-acting synthetic analog of the naturally occurring hormone amylin.
How Cagrilintide Works?
Cagrilintide functions as a dual receptor agonist, meaning it targets and activates two different receptor types: the amylin receptor and the calcitonin receptor. Its mechanism is centered around mimicking and prolonging the effects of the natural hormone amylin, which is co-secreted with insulin by the pancreas.
Its primary actions that lead to weight loss and improved metabolic health are:
- Enhances Satiety and Reduces Appetite: Cagrilintide binds to the amylin receptors in the brain's appetite-regulating centers. This action enhances signals of fullness and satiety, directly leading to a reduction in food intake and a decrease in overall caloric consumption.
- Delays Gastric Emptying: By acting on the amylin receptor, it slows down the rate at which food leaves the stomach. This mechanical delay contributes to a prolonged feeling of fullness after meals.
- Improves Glucose Regulation: The action of slowing gastric emptying helps to modulate post-meal blood sugar spikes, leading to more stable glucose levels, which is particularly beneficial for individuals with type 2 diabetes or prediabetes.
- Calcitonin Receptor Engagement: Activation of the calcitonin receptor, a secondary target, is thought to further contribute to energy balance and weight regulation, offering a more comprehensive approach than targeting the amylin pathway alone.
Synonyms of Cagrilintide
- Cagrilintide
- 1415456-99-3
- Cagrilintide [INN]
- RefChem:573322
- AO43BIF1U8
- L-PROLINAMIDE, N-(19-CARBOXY-1-OXONONADECYL)-L-.GAMMA.-GLUTAMYL-L-LYSYL-L-CYSTEINYL-L-ASPARAGINYL-L-THREONYL-L-ALANYL-L-THREONYL-L-CYSTEINYL-L-ALANYL-L-THREONYL-L-GLUTAMINYL-L-ARGINYL-L-LEUCYL-L-ALANYL-L-.ALPHA.-GLUTAMYL-L-PHENYLALANYL-L-LEUCYL-L-ARGINYL-L-HISTIDYL-L-SERYL-L-SERYL-L-ASPARAGINYL-L-ASPARAGINYL-L-PHENYLALANYLGLYCYL-L-PROLYL-L-ISOLEUCYL-L-LEUCYL-L-PROLYL-L-PROLYL-L-THREONYL-L-ASPARAGINYL-L-VALYLGLYCYL-L-SERYL-L-ASPARAGINYL-L-THREONYL-, CYCLIC (3->8)-DISULFIDE
- L-PROLINAMIDE, N-(19-CARBOXY-1-OXONONADECYL)-L-GAMMA-GLUTAMYL-L-LYSYL-L-CYSTEINYL-L-ASPARAGINYL-L-THREONYL-L-ALANYL-L-THREONYL-L-CYSTEINYL-L-ALANYL-L-THREONYL-L-GLUTAMINYL-L-ARGINYL-L-LEUCYL-L-ALANYL-L-ALPHA-GLUTAMYL-L-PHENYLALANYL-L-LEUCYL-L-ARGINYL-L-HISTIDYL-L-SERYL-L-SERYL-L-ASPARAGINYL-L-ASPARAGINYL-L-PHENYLALANYLGLYCYL-L-PROLYL-L-ISOLEUCYL-L-LEUCYL-L-PROLYL-L-PROLYL-L-THREONYL-L-ASPARAGINYL-L-VALYLGLYCYL-L-SERYL-L-ASPARAGINYL-L-THREONYL-, CYCLIC (3->8)-DISULFIDE
- GTPL13768
- LDERDVMBIYGIOI-IZVMHKDJSA-N
- EX-A10092
- AT42613
- analogue 23 [PMID: 34288673]
- NN0174-0833
External Sources about Cagrilintide
- Structural and mechanistic insights into dual activation of cagrilintide in amylin and calcitonin receptors (Research Article)
- Efficacy and Safety of Cagrilintide Alone and in Combination with Semaglutide (Cagrisema) as Anti-Obesity Medications: A Systematic Review and Meta-Analysis (PMC/NIH)
- Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity (Phase 3 Trial Data - PubMed)
- Cagrilintide/semaglutide (CagriSema) - Wikipedia (Summary of trials and mechanism)
- Investigating How CagriSema, Semaglutide and Cagrilintide Regulate Insulin Effects in the Body of People With Type 2 Diabetes (Clinical Trial Registry)